Fig. 6. TRPM2 downregulation reduces NSCLC tumor growth ability in SCID mice. (A) Representative in vivo image and the growth rate of scrambled and TRPM2-KD1 A549 tumours in NOD/SCID mice. Tumours were started to measure three weeks post subcutaneous injection every 3 days for around 6 weeks. Tumors were extracted and the final measurement of tumours volume and weight (B) as well as RT-qPCR analysis of EMT markers expression in tumors (C) were plotted (t test vs. scr. ***, p<0.001; **, p<0.01; *, p<0.05).